Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website http://www.cardiologyres.org

Original Article

Volume 11, Number 3, June 2020, pages 185-191

T-Peak to T-End Improvements After Beta-Blocker Administration in Peripartum Cardiomyopathy Patients

Figures

Figure 1.
Figure 1. Method of T-peak to T-end (TPTE) measurement in lead V5.
Figure 2.
Figure 2. Electrocardiogram example of the effect of beta-blockers on T-peak to T-end (TPTE) interval in a 31-year-old female with PPCM.
Figure 3.
Figure 3. Comparisons of variables between before and after beta-blocker treatment.
Figure 4.
Figure 4. Reduction of T-peak to T-end interval before and after administration of beta-blocker.

Tables

Table 1. Baseline Characteristics of Patients
 
VariableMean ± SD
SD: standard deviation; bpm: beats per minute; QTc: QT corrected; ACE: angiotensin-converting enzyme; MRA: mineralocorticoid receptor antagonist; LVEF: left ventricular ejection fraction.
Age (years)32 ± 6.4
Body mass index (kg/m2)24.87 ± 3.2
Blood pressure (mm Hg)
  Systolic118 ± 11.4
  Diastolic76 ± 6.9
ECG parameters114.85 ± 16.9
  Heart rate (bpm)64.42 ± 18.2
  QRS duration (ms)471.50 ± 440.2
  QTc interval (ms)
Heart failure medications, n (%)
  Beta-blockers34 (100)
  ACE inhibitor34 (100)
  Diuretics34 (100)
  MRA3 (8.8)
Echocardiographic data
  LVEF (%)32.24 ± 6.3
  Mitral E/A ratio1.73 ± 0.7
  Deceleration time147.68 ± 42.6

 

Table 2. Comparisons of Variables Between Before and After Beta-Blocker Treatment
 
VariableBefore treatmentAfter treatmentP value
LVEF: left ventricular ejection fraction; bpm: beats per minute; QTc: QT corrected; TPTE: T-peak to T-end. P value is considered significant if P < 0.05.
Heart rate (bpm)114.85 ± 16.970.65 ± 10.4< 0.001
LVEF (%)32.24 ± 6.358.26 ± 4.4< 0.001
Mitral E/A1.73 ± 0.71.36 ± 0.30.011
Deceleration time (ms)147.68 ± 42.6174.68 ± 33.90.001
QRS duration (ms)64.42 ± 18.260 ± 12.10.420
QTc interval (ms)471.50 ± 440.2440.17 ± 24.90.082
TPTE (ms)123.7 ± 28.298.7 ± 39.5< 0.001