Figures
Figure 1. Time course of systolic and diastolic blood pressures. Data are expressed as mean ± SD (n = 6 - 8 each). SD: standard deviation. *P < 0.05 vs. sham-operated group.
Figure 2. Echocardiographic analysis pre-Ang II infusion and post-3 weeks of Ang II infusion. Data are expressed as mean ± SD (n = 6 - 8 each). IVSTd: interventricular septum thickness diameter; LVPWd: left ventricular posterior wall thickness diameter; LVMI: left ventricular mass index. *P < 0.05 vs. sham-operated group; †P < 0.05.
Figure 3. Histological analyses for the cardiomyocytes of left ventricle. (a) Representative photographs of higher magnification views of hematoxylin-eosin-stained heart sections. (b) Quantitative analysis for the cross-sectional area of individual cardiomyocytes. Data are expressed as mean ± SD. SD: standard deviation; SAC/VAL: sacubitril/valsartan-treated group. *P < 0.05 vs. sham-operated group; †P < 0.05 vs. vehicle-treated control group.
Figure 4. Histological analyses for the cardiac fibrosis. (a) Representative photographs of the picro-sirius red-stained whole heart sections. (b) Quantitative analyses for the left ventricular fibrosis. Data are expressed as mean ± SD. SAC/VAL: sacubitril/valsartan-treated group; SD: standard deviation.
Figure 5. Relative expression of genes of interest by the quantitative polymerase chain reaction. Data are expressed as mean ± SD (n = 6 - 8 each). SD: standard deviation; ANP: atrial natriuretic peptide; BNP: B-type natriuretic peptide; TGF-β: transforming growth factor-β; SAC/VAL: sacubitril/valsartan-treated group. *P < 0.05 vs. sham-operated group.