| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc |
| Journal website https://www.cardiologyres.org |
Review
Volume 11, Number 6, December 2020, pages 356-359
Lipoprotein(a) and Familial Hypercholesterolemia: A Short Review Including the Laboratory Viewpoint
Tables
| Studies | Genea | FH (-) | FH (+) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects (n) | Age (years) | Lp(a) (mg/dL)b | LDL-C (mmol/L)c | Subjects (n) | Age (years) | Lp(a) (mg/dL)b | LDL-C (mmol/L)c | ||
| aGene used for diagnosis of FH; bLp(a) expressed as a median value; cLDL-C expressed as a mean value. FH: familial hypercholesterolemia; Lp(a): lipoprotein(a); LDL-C: low-density lipoprotein cholesterol; LDLR: low-density lipoprotein receptor; PCSK9: proprotein convertase subtilisin/kexin type 9. | |||||||||
| Lingenhel et al, 1998 [5] | LDLR | 57 | - | 16.3 | 5.3 | 103 | - | 27.7 | 8.7 |
| Alonso et al, 2014 [6] | LDLR | 957 | 40.6 | 21 | 3.4 | 1,960 | 44.4 | 23.6 | 4.8 |
| Tada et al, 2016 [7] | LDLR | 4,015 | 58 | 11.8 | 2.8 | 198 | 42 | 21.9 | 5.6 |
| PCSK9 | - | - | - | - | 42 | 52 | 21.1 | 6.1 | |
| Studies | CVD (-) | CVD (+) | ||||
|---|---|---|---|---|---|---|
| Subjects (n) | Age (years) | Lp(a) (mg/dL)a | Subjects (n) | Age (years) | Lp(a) (mg/dL)a | |
| aLp(a) expressed as a median (interquartile range). FH: familial hypercholesterolemia; CVD: cardiovascular disease; Lp(a): lipoprotein(a). | ||||||
| Allard et al, 2014 [10] | 221 | 58 | 26.3 (10.4 - 60.5) | 74 | 67.7 | 34.9 (12.2 - 84.1) |
| Alonso et al, 2014 [6] | 1,713 | - | 21.3 (8.9 - 53.9) | 247 | - | 43.4 (18.2 - 84.3) |
| Chan et al, 2015 [11] | 326 | 43 | 39 (34 - 44) | 64 | 57 | 59 (44 - 75) |
| Sun et al, 2018 [12] | 87 | 45 | 21.5 (7.95 - 46.1) | 61 | 49 | 34.7 (16.2 - 68.1) |