Figures
Figure 1. Dynamics of alterations in SP and DP in experimental rats. 1: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks; 2: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks followed by 3 weeks of spontaneous recovery; 3: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks (4 + 3 weeks); 4: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks, from the beginning of the fifth week (weeks 5 - 7), intraperitoneal administration of L-arginine (300 mg/kg) was added. SP: systolic pressure; DP: diastolic pressure; L-NAME: N-nitro-methyl ether-L-arginine.
Figure 2. Dynamics of alterations of indicators of pulse rate and PP in experimental rats. 1: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks; 2: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks followed by 3 weeks of spontaneous recovery; 3: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks (4 + 3 weeks); 4: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks, from the beginning of the fifth week (weeks 5 - 7), intraperitoneal administration of L-arginine (300 mg/kg) was added. PP: pulse pressure; L-NAME: N-nitro-methyl ether-L-arginine.
Figure 3. Dynamics of alterations of NO content in the rats’ arterial and venous blood. 1: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks; 2: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 4 weeks followed by 3 weeks of spontaneous recovery; 3: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks (4 + 3 weeks); 4: rats with intraperitoneal administration of L-NAME (40 mg/kg) for 7 weeks, from the beginning of the fifth week (weeks 5 - 7), intraperitoneal administration of L-arginine (300 mg/kg) was added. NO: nitric oxide; L-NAME: N-nitro-methyl ether-L-arginine.
Figure 4. The overall correlation and its statistical significance between NO and PP levels (combined group including parameters of subgroups I, IIa, IIb and IIc). NO: nitric oxide; PP: pulse pressure.
Tables
Table 1. Morphometric Parameters of Carotid Artery
| Groups | ID (µm) | WT (µm) |
|---|
| *P < 0.01 vs. controls. **P < 0.01 vs. L-NAME. ID: inner diameter; WT: wall thickness; L-NAME: N-nitro-methyl ether-L-arginine. |
| Group I | 825 ± 25.5 | 21.39 ± 0.85 |
| Group IIa | 832 ± 22.6 | 30.21 ± 0.89* |
| Group IIb | 829 ± 23.0 | 31.54 ± 0.85* |
| Group IIc | 828 ± 26.7 | 33.53 ± 3.41* |
| Group III | 827 ± 24.5 | 24.56 ± 2.45** |
Table 2. Correlation and Its Statistical Significance Between NO and PP Levels Within Groups
| Groups | r | P |
|---|
| NO: nitric oxide; PP: pulse pressure. |
| Group I (control) | -0.68 | 0.06 |
| Group IIa | -0.72 | 0.045 |
| Group IIb | -0.7 | 0.06 |
| Group IIc | -0.73 | 0.06 |
| Group III | -0.75 | 0.05 |