| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc |
| Journal website https://www.cardiologyres.org |
Review
Volume 15, Number 4, August 2024, pages 211-222
Advances in the Diagnosis and Management of Cardiac Amyloidosis: A Literature Review
Table
| Therapy | Number of participants | Outcome (survival/stabilization) | Primary trial findings |
|---|---|---|---|
| TTR: transthyretin; ATTR: amyloid transthyretin. | |||
| Tafamidis [73] | 441 | Improved survival and reduced cardiovascular-related hospitalizations | Effective in stabilizing transthyretin protein, slowing disease progression |
| Acoramidis [74] | 632 | Improved exercise capacity and quality of life | Superior stabilization of TTR tetramers, effective across various genetic forms of ATTR |
| Patisiran [75] | 148 | Improved cardiac markers and quality of life | Significant reduction in amyloid burden, though impact on mortality and hospitalization still under study |
| Vutrisiran [76] | 122 | Improved cardiac biomarkers and functional capacity | Promising results in reducing amyloid production and improving cardiac health |