| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc |
| Journal website https://www.cardiologyres.org |
Review
Volume 15, Number 5, October 2024, pages 340-349
Advances in the Understanding and Treatment of Chronic Chagas Cardiomyopathy
Table
| Features | Chronic Chagas cardiomyopathy (CCC) | Arrhythmogenic cardiomyopathy (AC) |
|---|---|---|
| MRI: magnetic resonance imaging. | ||
| Risk factors | Rural Latin America | Family history (autosomal dominant) |
| Causes | Trypanosoma cruzi infection | Genetic mutations |
| Pathophysiology | Dysautonomia | Fibrofatty infiltration |
| Heart failure | Common | Common |
| Ventricular arrhythmias | Common | Common |
| Thromboembolism | Common | Rare |
| Ventricular aneurysms | Common (apical aneurysms) | Rare |
| Right ventricular involvement | Rare | Common (dilation) |
| Heart block | Common (complete) | Rare (first-degree) |
| Chest pain | Common (atypical) | Rare |
| Disease-specific finding | Common (megaesophagus, megacolon) | Rare |
| Diagnostic test | Transthoracic echocardiogram | Cardiac MRI |
| Treatment | Benznidazole, angiotensin-converting enzyme inhibitors, beta-adrenergic blockers, diuretics | Beta-adrenergic blockers, angiotensin-converting enzyme inhibitors, antiarrhythmic drugs, implantable cardioverter-defibrillators |
| Complications | Heart failure | Sudden cardiac death |