Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website https://www.cardiologyres.org

Original Article

Volume 3, Number 5, October 2012, pages 214-221

Relationship Between Brachial Artery Flow-Mediated Dilation, Carotid Artery Intima-Media Thickness and Coronary Flow Reserve in Patients With Coronary Artery Disease

Figures

Figure 1.
Figure 1. Relationship between coronary flow reserve (CFR) values and intima-media thickness of all subjects in study group (r = -0.403, P < 0.001).
Figure 2.
Figure 2. Relationship between coronary flow reserve (CFR) values and flow mediated dilation (FMD) of all subjects in study group (r = 0.232, P < 0.05).
Figure 3.
Figure 3. Relationship between flow mediated dilation (FMD) and intima-media thickness (IMT) of all subjects in study group (r = -0.211, P < 0.05).

Tables

Table 1. Clinical Characteristics of the Subjects and CAD Patients
 
CAD (n = 50)Control (n = 45)P
NS: not significant; BMI: Body-Mass Index.
Age (year)52.4 ± 6.449.8 ± 8.9NS
Male/Female40/1036/9NS
BMI (kg/m2)26.2 ± 3.4426.1 ± 2.94NS
Hypertension32 (64%)9 (20%)< 0.05
Diabetes Mellitus7 (14%)-
Smoke37 (74%)30 (66.7%)NS
Systolic pressure (mmHg)126.9 ± 15.76123 ± 17.160.39
Diastolic pressure (mmHg)79.2 ± 9.6477.44 ± 8.380.19
Total Chol (mg/dL)186.9 ± 41.5195.4 ± 30.8NS
Triglyceride (mg/dL)158.18 ± 84138.08 ± 38.51NS
HDL (mg/dL)38.24 ± 8.7142.75 ± 6.06< 0.05
LDL (mg/dL)112.04 ± 34.69130.02 ± 27.78< 0.05
Creatinin (mg/dL)0.94 ± 0.230.83 ± 0.13NS
Hgb (g/dL)13.7 ± 1.0314.09 ± 1.61NS
Medical Treatment
  ACE inhibitor35 (70%)5 (20%)< 0.001
  Beta blocker37 (74%)3< 0.001
  Calcium C. blocker2 (4%)1NS
  Aspirin48 (96%)2< 0.0001
  Statin45 (90%)1< 0.0001

 

Table 2. Echocardiographical Features of the Control and the CAD Patients
 
CAD (n = 50)Control (n = 45)P
BPDV: blsal peak diastolic velocity; HPDV: Hyperemic peak diastolic velocity.
EF (%)56% ± 7.3364% ± 4.59< 0.05
LVMI (g/m2)109 ± 25.4885.74 ± 16.91< 0.005
IMK (mm)0.89 ± 0.240.64 ± 0.17< 0.005
FMD (%)5.03 ± 4.247.47 ± 2.94= 0.02
BPDV (cm/sn)32.68 ± 10.2029.37 ± 8.49= 0.09
HPDV (cm/sn)55.88 ± 17.5869.13 ± 27.41= 0.06
CFR1.75 ± 0.462.40 ± 0.80< 0.005