Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website https://www.cardiologyres.org

Original Article

Volume 4, Number 2, April 2013, pages 56-63


Effects of Uric Acid on Lipid Levels in CKD Patients in a Randomized Controlled Trial

Figures

Figure 1.
Figure 1. Simple scatterplot for uric acid and apolipoprotein B.
Figure 2.
Figure 2. Simple scatterplot for total cholesterol and uric acid.
Figure 3.
Figure 3. Simple scatterplot for LDL and uric acid.

Tables

Table 1. Demographic and Pretest Values for Treatment and Control Groups
 
VariableAllopurinol Group (n = 12)Placebo Group (n = 12)P-value
CRP, uric acid, and albumin are measured in mg/dL; IL-6, IL-1β, and TNF-α are measured in pg/mL.
Gender, n (%)0.667
  Females3 (25.0)7 (58.3)
  Males9 (75.0)5 (41.7)
Age, y (SD)59.2 (10.1)62.4 (9.5)0.307
Ethnicity, n (%)0.197
  African American4 (33.3)8 (66.7)
  Caucasian4 (33.3)1 (8.3)
  Hispanic4 (33.3)3 (25.0)
Weight (kg), mean (SD)86.31 (14.10)88.35 (31.54)0.138
Systolic BP, mean (SD)142.17 (14.30)139.25 (30.07)0.764
Diastolic BP, mean (SD)76.17 (9.97)73.67 (15.92)0.649
GFR, mean (SD)47.30 (15.90)45.10 (19.80)0.503
Diabetes, n (%)8 (66.7)5 (41.7)0.154
CRP, mean (SD)7.73 (2.06)8.87 (3.18)0.717
IL-6, mean (SD)21.76 (14.43)17.38 (12.46)0.327
TNF-α, mean (SD)22.10 (9.91)23.33 (11.76)0.703
Albumin, mean (SD)4.24 (0.24)4.11 (0.43)0.445

 

Table 2. Pretest (t-Test) and Posttest (ANCOVA) Lipid Values for the Allopurinol Group and the Control Group
 
Variable*Allopurinol Group (n = 12)Placebo Group (n = 12)P-value
HDL, LDL, total cholesterol and apolipoprotein B are measured in mg/dL.
Pre HDL39.08 (13.48)35.75 (7.30)0.452
Post HDL36.40 (14.72)38.30 (9.63)0.762
Pre LDL97.00 (40.68)114.92 (34.77)0.707
Post LDL96.10 (32.46)119.56 (42.05)0.052
Pre Triglycerides126.83 (42.88)135.25 (75.27)0.408
Post Triglycerides161.20 (89.67)176.50 (117.96)0.403
Pre Total Cholesterol161.42 (38.23)177.58 (41.13)0.741
Post Total cholesterol164.80 (35.97)188.00 (44.46)0.009
Pre Total Cholesterol- HDL Ratio4.55 (1.92)5.21 (1.88)0.405
Post Total Cholesterol- HDL Ratio5.06 (2.15)5.18 (1.70)0.455
Pre Apolipoprotein B78.58 (25.96)92.25 (22.86)0.886
Post Apolipoprotein B79.30 (24.15)100.30 (25.46)0.006
Pre Uric Acid7.73 (2.06)8.87 (3.18)0.307
Post Uric Acid6.50 (1.78)8.61 (3.30)0.034
Pre GFR47.30 (15.90)45.10 (19.80)0.407
Post GFR45.19 (13.56)41.15 (18.76)0.578
Pre Creatinine1.57 (0.61)2.10 (0.88)0.307
Post Creatinine1.62 (.64)2.11 (0.97)0.185