Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 4, Number 2, April 2013, pages 56-63

Effects of Uric Acid on Lipid Levels in CKD Patients in a Randomized Controlled Trial

**Table 1.** Demographic and Pretest Values for Treatment and Control Groups
Variable	Allopurinol Group (n = 12)	Placebo Group (n = 12)	P-value
CRP, uric acid, and albumin are measured in mg/dL; IL-6, IL-1β, and TNF-α are measured in pg/mL.
Gender, n (%)			0.667
Females	3 (25.0)	7 (58.3)
Males	9 (75.0)	5 (41.7)
Age, y (SD)	59.2 (10.1)	62.4 (9.5)	0.307
Ethnicity, n (%)			0.197
African American	4 (33.3)	8 (66.7)
Caucasian	4 (33.3)	1 (8.3)
Hispanic	4 (33.3)	3 (25.0)
Weight (kg), mean (SD)	86.31 (14.10)	88.35 (31.54)	0.138
Systolic BP, mean (SD)	142.17 (14.30)	139.25 (30.07)	0.764
Diastolic BP, mean (SD)	76.17 (9.97)	73.67 (15.92)	0.649
GFR, mean (SD)	47.30 (15.90)	45.10 (19.80)	0.503
Diabetes, n (%)	8 (66.7)	5 (41.7)	0.154
CRP, mean (SD)	7.73 (2.06)	8.87 (3.18)	0.717
IL-6, mean (SD)	21.76 (14.43)	17.38 (12.46)	0.327
TNF-α, mean (SD)	22.10 (9.91)	23.33 (11.76)	0.703
Albumin, mean (SD)	4.24 (0.24)	4.11 (0.43)	0.445

Table 1. Demographic and Pretest Values for Treatment and Control Groups

Variable

Allopurinol Group (n = 12)

Placebo Group (n = 12)

P-value

CRP, uric acid, and albumin are measured in mg/dL; IL-6, IL-1β, and TNF-α are measured in pg/mL.

Gender, n (%)

0.667

Females

3 (25.0)

7 (58.3)

Males

9 (75.0)

5 (41.7)

Age, y (SD)

59.2 (10.1)

62.4 (9.5)

0.307

Ethnicity, n (%)

0.197

African American

4 (33.3)

8 (66.7)

Caucasian

4 (33.3)

1 (8.3)

Hispanic

4 (33.3)

3 (25.0)

Weight (kg), mean (SD)

86.31 (14.10)

88.35 (31.54)

0.138

Systolic BP, mean (SD)

142.17 (14.30)

139.25 (30.07)

0.764

Diastolic BP, mean (SD)

76.17 (9.97)

73.67 (15.92)

0.649

GFR, mean (SD)

47.30 (15.90)

45.10 (19.80)

0.503

Diabetes, n (%)

8 (66.7)

5 (41.7)

0.154

CRP, mean (SD)

7.73 (2.06)

8.87 (3.18)

0.717

IL-6, mean (SD)

21.76 (14.43)

17.38 (12.46)

0.327

TNF-α, mean (SD)

22.10 (9.91)

23.33 (11.76)

0.703

Albumin, mean (SD)

4.24 (0.24)

4.11 (0.43)

0.445

**Table 2.** Pretest (t-Test) and Posttest (ANCOVA) Lipid Values for the Allopurinol Group and the Control Group
Variable*	Allopurinol Group (n = 12)	Placebo Group (n = 12)	P-value
HDL, LDL, total cholesterol and apolipoprotein B are measured in mg/dL.
Pre HDL	39.08 (13.48)	35.75 (7.30)	0.452
Post HDL	36.40 (14.72)	38.30 (9.63)	0.762
Pre LDL	97.00 (40.68)	114.92 (34.77)	0.707
Post LDL	96.10 (32.46)	119.56 (42.05)	0.052
Pre Triglycerides	126.83 (42.88)	135.25 (75.27)	0.408
Post Triglycerides	161.20 (89.67)	176.50 (117.96)	0.403
Pre Total Cholesterol	161.42 (38.23)	177.58 (41.13)	0.741
Post Total cholesterol	164.80 (35.97)	188.00 (44.46)	0.009
Pre Total Cholesterol- HDL Ratio	4.55 (1.92)	5.21 (1.88)	0.405
Post Total Cholesterol- HDL Ratio	5.06 (2.15)	5.18 (1.70)	0.455
Pre Apolipoprotein B	78.58 (25.96)	92.25 (22.86)	0.886
Post Apolipoprotein B	79.30 (24.15)	100.30 (25.46)	0.006
Pre Uric Acid	7.73 (2.06)	8.87 (3.18)	0.307
Post Uric Acid	6.50 (1.78)	8.61 (3.30)	0.034
Pre GFR	47.30 (15.90)	45.10 (19.80)	0.407
Post GFR	45.19 (13.56)	41.15 (18.76)	0.578
Pre Creatinine	1.57 (0.61)	2.10 (0.88)	0.307
Post Creatinine	1.62 (.64)	2.11 (0.97)	0.185

Table 2. Pretest (t-Test) and Posttest (ANCOVA) Lipid Values for the Allopurinol Group and the Control Group

Variable*

Allopurinol Group (n = 12)

Placebo Group (n = 12)

P-value

HDL, LDL, total cholesterol and apolipoprotein B are measured in mg/dL.

Pre HDL

39.08 (13.48)

35.75 (7.30)

0.452

Post HDL

36.40 (14.72)

38.30 (9.63)

0.762

Pre LDL

97.00 (40.68)

114.92 (34.77)

0.707

Post LDL

96.10 (32.46)

119.56 (42.05)

0.052

Pre Triglycerides

126.83 (42.88)

135.25 (75.27)

0.408

Post Triglycerides

161.20 (89.67)

176.50 (117.96)

0.403

Pre Total Cholesterol

161.42 (38.23)

177.58 (41.13)

0.741

Post Total cholesterol

164.80 (35.97)

188.00 (44.46)

0.009

Pre Total Cholesterol- HDL Ratio

4.55 (1.92)

5.21 (1.88)

0.405

Post Total Cholesterol- HDL Ratio

5.06 (2.15)

5.18 (1.70)

0.455

Pre Apolipoprotein B

78.58 (25.96)

92.25 (22.86)

0.886

Post Apolipoprotein B

79.30 (24.15)

100.30 (25.46)

0.006

Pre Uric Acid

7.73 (2.06)

8.87 (3.18)

0.307

Post Uric Acid

6.50 (1.78)

8.61 (3.30)

0.034

Pre GFR

47.30 (15.90)

45.10 (19.80)

0.407

Post GFR

45.19 (13.56)

41.15 (18.76)

0.578

Pre Creatinine

1.57 (0.61)

2.10 (0.88)

0.307

Post Creatinine

1.62 (.64)

2.11 (0.97)

0.185