Cardiology Research, ISSN 1923-2829 print, 1918-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, the Cardiol Res and Elmer Press Inc
Journal website https://www.cardiologyres.org
 

Cardioprotective Effects of Oral Trimetazidine in Diabetic Patients With Anterior Wall Myocardial Infarction Treated with Thrombolysis
 
Tables


 

Table 1. Baseline Characteristics of the Two Study Groups
 

Variable

Group A (n = 50)

Group B (n = 50)

P value*

Age (years)

59.6 ± 5.4

58.5 ± 2.3

> 0.05

Males

31 (62)

29 (58)

> 0.05

Hypertension

24 (48)

25 (50)

> 0.05

Dyslipidemia

20 (40)

21 (42)

> 0.05

Smoking

15 (30)

17 (34)

> 0.05

Baseline CK-T (U/L)

222 ± 8.4

218 ± 6.4

> 0.05

Baseline CK-MB (U/L)

8.9 ± 2.4

9.3 ± 3.6

> 0.05

HbA1c (%)

7.2 ± 0.2

7.1 ± 0.3

> 0.05

CK-T: creatine kinase-total; CK-MB: creatine kinase-MB isoenzmye; HbA1c: glycated hemoglobin. Categorical variables are presented as number (percentage). Continuous variables are presented as mean ± standard deviation. *Pearson Chi-square and Student’s t-test. 


 

Table 2. Echocardiographic Data of Both Study Groups (24 - 48 h After Thrombolysis and 6 Months Later)
 

 

Baseline

After 6 months

P value*

Group A (n = 50)

 

 

 

LVEF (%)

33.1 ± 4.5

39.5 ± 5.9

< 0.001

LVEDV (mL)

183 ± 12.7

181.8 ± 13

> 0.05

LVESV (mL)

121.8 ± 9.2

110.2 ± 13

< 0.05

WMSI

1.64 ± 0.3

1.29 ± 0.2

< 0.05

Group B (n = 47)

 

 

 

LVEF (%)

33.4 ± 3.5

33.6 ± 3.4

> 0.05

LVEDV (mL)

181 ± 19.9

180.7 ± 18

> 0.05

LVESV (mL)

113.7 ± 11.7

110 ± 22

> 0.05

WMSI

1.7 ± 0.3

1.64 ± 0.4

> 0.05

LVEF: left ventricle ejection fraction, LVEDV: left ventricle end diastolic volume; LVESV: left ventricle end systolic volume; WMSI: wall motion score index. All variables are presented as mean ± standard deviation. *Student’s t-test. 


 

Table 3. Recorded Adverse Events for Both Study Groups (During In-Hospital Stay and After 6 Months)
 

Variable

Group A (n = 50)

Group B (n = 50)

P value*

In-hospital

 

 

 

HF

5 (10)

7 (14)

> 0.05

Sustained VA

4 (8)

5 (10)

> 0.05

LV thrombus

4 (8)

6 (12)

> 0.05

Recurrence of angina

8 (16)

6 (12)

> 0.05

Re-infarction

0

2 (4)

> 0.05

Cerebrovascular stroke

0

1 (2)

> 0.05

Six months

 

 

 

Cardiac mortality

0

3 (6)

< 0.05

Hospitalization for HF

3 (6)

10 (20)

< 0.05

Re-infarction

1 (2)

5 (10)

< 0.05

HF: heart failure; VA: ventricular arrhythmia; LV: left ventricle. All variables are presented as number (percentage). *Pearson Chi-square and Fisher exact tests.