Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 5, Number 6, December 2014, pages 176-182

Effects of Left Ventricular Wall Motion Abnormality on Global and Regional Diastolic Function of the Left and Right Ventricles at Rest and After Stress

**Table 1.** Global Left Ventricular Diastolic Filling Parameters at Rest and After DSE
		MV-E (cm/s)	MV-A (cm/s)	MV-E/A	EDT (ms)	MV-CS (cm/s)	PV-D (cm/s)	PV-S (cm/s)	PV-D/S
A: late diastolic A-wave peak velocity; E: early diastolic mitral E-wave peak velocity; MV: mitral valve; CS: early diastolic color slope; EDT: mitral E-wave deceleration time; PV: pulmonary vein; D: peak diastolic velocity; S: peak systolic velocity.
Rest	Abnormal	69 ± 22	78 ± 17	0.93 ± 0.42	205 ± 74.1	50.5 ± 12.6	46.8 ± 13.8	54.4 ± 14.75	0.83 ± 0.475
Normal	79 ± 15	77.9 ± 16.5	1.02 ± 0.25	165.4 ± 30.5	49.45 ± 12.2	51.76 ± 12.37	61.2 ± 13.55	0.887 ± 0.295
P	0.16	0.6	0.517	0.215	0.82	0.274	0.173	0.653
DSE	Abnormal	65 ± 0.12	103 ± 0.15	0.64 ± 0.13		50.4 ± 13.2	58.1 ± 22.6	69.4 ± 33.71	0.361 ± 1.357
Normal	83 ± 0.17	111 ± 0.27	0.79 ± 0.23		62.5 ± 15.2	63.07 ± 20.35	87.15 ± 20.9	0.758 ± 0.348
P	0.0014	0.22	0.017		0.0224	0.537	0.14	0.382
P (rest:DSE)	Abnormal	0.558	0.0015	0.0296		0.982	0.187	0.216	0.215
Normal	0.222	6.37 × 10^-7	9.67 × 10^-5		5.83 × 10^-5	0.0038	7.81 × 10^-9	0.079

Table 1. Global Left Ventricular Diastolic Filling Parameters at Rest and After DSE

MV-E (cm/s)

MV-A (cm/s)

MV-E/A

EDT (ms)

MV-CS (cm/s)

PV-D (cm/s)

PV-S (cm/s)

PV-D/S

A: late diastolic A-wave peak velocity; E: early diastolic mitral E-wave peak velocity; MV: mitral valve; CS: early diastolic color slope; EDT: mitral E-wave deceleration time; PV: pulmonary vein; D: peak diastolic velocity; S: peak systolic velocity.

Rest

Abnormal

69 ± 22

78 ± 17

0.93 ± 0.42

205 ± 74.1

50.5 ± 12.6

46.8 ± 13.8

54.4 ± 14.75

0.83 ± 0.475

Normal

79 ± 15

77.9 ± 16.5

1.02 ± 0.25

165.4 ± 30.5

49.45 ± 12.2

51.76 ± 12.37

61.2 ± 13.55

0.887 ± 0.295

0.16

0.6

0.517

0.215

0.82

0.274

0.173

0.653

DSE

Abnormal

65 ± 0.12

103 ± 0.15

0.64 ± 0.13

50.4 ± 13.2

58.1 ± 22.6

69.4 ± 33.71

0.361 ± 1.357

Normal

83 ± 0.17

111 ± 0.27

0.79 ± 0.23

62.5 ± 15.2

63.07 ± 20.35

87.15 ± 20.9

0.758 ± 0.348

0.0014

0.22

0.017

0.0224

0.537

0.14

0.382

P (rest:DSE)

Abnormal

0.558

0.0015

0.0296

0.982

0.187

0.216

0.215

Normal

0.222

6.37 × 10^-7

9.67 × 10^-5

5.83 × 10^-5

0.0038

7.81 × 10^-9

0.079

**Table 2.** Regional Left Ventricular Diastolic Tissue Doppler Parameters at Rest and After Stress
		E_IVS (cm/s)	E_Lat (cm/s)	E_inf (cm/s)	E_ant (cm/s)	E_posterior (cm/s)	E_RV (cm/s)	A_IVS (cm/s)	A_Lat (cm/s)	A_inf (cm/s)	A_ant (cm/s)	A_posterior (cm/s)	A_RV (cm/s)
A: late diastolic A-wave peak velocity; E: early diastolic mitral E-wave peak velocity; ant: anterior; inf: inferior; IVS: inter-ventricular septum; Lat: lateral; RV: right ventricle.
Rest	Abnormal	9.63 ± 2.57	11 ± 3.1	9.34 ± 2.6	10.95 ± 2.96	10.2 ± 2.3	16.79 ± 7.15	12.2 ± 2.8	12.9 ± 4.6	13.3 ± 2.3	14.4 ± 5.2	14.1 ± 2.19	19.4 ± 5.3
	Normal	11.9 ± 3.8	14 ± 3.8	13 ± 3.7	13.6 ± 3.8	12.4 ± 3.2	16.3 ± 3.39	12.9 ± 2.4	13.9 ± 2.64	14.6 ± 3.1	14 ± 3.5	14.7 ± 3.3	20.1 ± 6.1
	P	0.0226	0.01	0.001456	0.02779	0.02476	0.8403	0.429	0.488	0.147	0.805	0.483	0.74
DSE	Abnormal	12.1 ± 3.2	14.2 ± 4.5	10.3 ± 1.98	13.1 ± 5.25	11.2 ± 3.1	17.44 ± 8.6	17.2 ± 4.5	17 ± 5.8	19.6 ± 3.7	20.4 ± 6.4	18.4 ± 4	26.7 ± 4.1
	Normal	12.6 ± 3.6	15.7 ± 4.1	13.4 ± 3.7	14.5 ± 5.1	13.3 ± 3.9	17.02 ± 5.92	17.7 ± 4.1	17 ± 3.4	19.1 ± 3.6	18.1 ± 5.7	19.5 ± 4.8	28.3 ± 6.9
	P	0.665	0.33	0.001012	0.445	0.0879	0.884	0.768	0.96	0.733	0.338	0.474	0.36
P (rest:DSE)	Abnormal	0.0558	0.064	0.335	0.289	0.441	0.853	0.0074	0.072	0.00036	0.0417	0.00981	0.005
	Normal	0.37	0.058	0.665	0.383	0.2686	0.503	1.69 × 10^-8	3.9 × 10^-5	7.29 × 10^-8	0.00033	2.02 × 10^-6	2.4 × 10^-7

Table 2. Regional Left Ventricular Diastolic Tissue Doppler Parameters at Rest and After Stress

E_IVS (cm/s)

E_Lat (cm/s)

E_inf (cm/s)

E_ant (cm/s)

E_posterior (cm/s)

E_RV (cm/s)

A_IVS (cm/s)

A_Lat (cm/s)

A_inf (cm/s)

A_ant (cm/s)

A_posterior (cm/s)

A_RV (cm/s)

A: late diastolic A-wave peak velocity; E: early diastolic mitral E-wave peak velocity; ant: anterior; inf: inferior; IVS: inter-ventricular septum; Lat: lateral; RV: right ventricle.

Rest

Abnormal

9.63 ± 2.57

11 ± 3.1

9.34 ± 2.6

10.95 ± 2.96

10.2 ± 2.3

16.79 ± 7.15

12.2 ± 2.8

12.9 ± 4.6

13.3 ± 2.3

14.4 ± 5.2

14.1 ± 2.19

19.4 ± 5.3

Normal

11.9 ± 3.8

14 ± 3.8

13 ± 3.7

13.6 ± 3.8

12.4 ± 3.2

16.3 ± 3.39

12.9 ± 2.4

13.9 ± 2.64

14.6 ± 3.1

14 ± 3.5

14.7 ± 3.3

20.1 ± 6.1

0.0226

0.01

0.001456

0.02779

0.02476

0.8403

0.429

0.488

0.147

0.805

0.483

0.74

DSE

Abnormal

12.1 ± 3.2

14.2 ± 4.5

10.3 ± 1.98

13.1 ± 5.25

11.2 ± 3.1

17.44 ± 8.6

17.2 ± 4.5

17 ± 5.8

19.6 ± 3.7

20.4 ± 6.4

18.4 ± 4

26.7 ± 4.1

Normal

12.6 ± 3.6

15.7 ± 4.1

13.4 ± 3.7

14.5 ± 5.1

13.3 ± 3.9

17.02 ± 5.92

17.7 ± 4.1

17 ± 3.4

19.1 ± 3.6

18.1 ± 5.7

19.5 ± 4.8

28.3 ± 6.9

0.665

0.33

0.001012

0.445

0.0879

0.884

0.768

0.96

0.733

0.338

0.474

0.36

P (rest:DSE)

Abnormal

0.0558

0.064

0.335

0.289

0.441

0.853

0.0074

0.072

0.00036

0.0417

0.00981

0.005

Normal

0.37

0.058

0.665

0.383

0.2686

0.503

1.69 × 10^-8

3.9 × 10^-5

7.29 × 10^-8

0.00033

2.02 × 10^-6

2.4 × 10^-7

**Table 3.** Ratio of Early and Late Diastolic Mitral Peak Velocities to Regional Left Ventricular Doppler Diastolic Peak Velocities at Rest and After Stress
		MV-E/E_IVS	MV-E/E_Lat	MV-E/E_inf	MVE/Eant	MV-E/E_posterior	MV-E/E_RV	MV-A/A_IVS	MV-A/A_Lat	MV-A/A_inf	MVA/A_ant	MV-A/A_posterrior	MV-A/A_RV
Abbreviations as in Tables 1 and 2.
Rest	Abnormal	7 ± 1.9	5.7 ± 1.8	7 ± 2	6 ± 1.5	6 ± 1.7	4.48 ± 1.9	6.4 ± 0.5	5.7 ± 1.6	5.8 ± 1.2	5.7 ± 1.5	5.5 ± 1.5	0.04 ± 0.12
Normal	7 ± 3	6 ± 2	6.7 ± 2.6	6.3 ± 2.3	7 ± 2.4	4.89 ± 1.5	6.5 ± 1.3	6 ± 2	5.8 ± 2.2	6.2 ± 2.2	5.8 ± 2	0.045 ± 0.019
P	0.59	0.576	0.66	0.547	0.414	0.369	0.735	0.48	0.884	0.434	0.512	0.805
DSE	Abnormal	5.8 ± 2	4.9 ± 1.4	2.5 ± 0. 7	6 ± 2	6.3 ± 1.5	5.1 ± 2.5	6.5 ± 2.2	6.6 ± 1.6	6 ± 2	6.5 ± 2	6 ± 2.2	0.039 ± 0.006
Normal	7 ± 3	5.6 ± 1.9	3 ± 1.3	6.3 ± 2.4	6.6 ± 2.6	5.49 ± 2.5	6.4 ± 1.5	6 ± 1.5	5.4 ± 1.5	5.4 ± 1.6	5.9 ± 1.3	0.04 ± 0.017
P	0.0795	0.207	0.122	0.47	0.63	0.375	0.93	0.326	0.29	0.122	0.77	0.46
P	Abnormal	0.147	0.25	2.93 × 10^-5	0.823	0.903	0.619	0.947	0.549	0.57	0.749	0.513	0.33
(rest:DSE)	Normal	0.83	0.32	5.15 × 10^-11	0.96	0.57	0.482	0.865	0.269	0.85	0.575	0.663	0.41

Table 3. Ratio of Early and Late Diastolic Mitral Peak Velocities to Regional Left Ventricular Doppler Diastolic Peak Velocities at Rest and After Stress

MV-E/E_IVS

MV-E/E_Lat

MV-E/E_inf

MVE/Eant

MV-E/E_posterior

MV-E/E_RV

MV-A/A_IVS

MV-A/A_Lat

MV-A/A_inf

MVA/A_ant

MV-A/A_posterrior

MV-A/A_RV

Abbreviations as in Tables 1 and 2.

Rest

Abnormal

7 ± 1.9

5.7 ± 1.8

7 ± 2

6 ± 1.5

6 ± 1.7

4.48 ± 1.9

6.4 ± 0.5

5.7 ± 1.6

5.8 ± 1.2

5.7 ± 1.5

5.5 ± 1.5

0.04 ± 0.12

Normal

7 ± 3

6 ± 2

6.7 ± 2.6

6.3 ± 2.3

7 ± 2.4

4.89 ± 1.5

6.5 ± 1.3

6 ± 2

5.8 ± 2.2

6.2 ± 2.2

5.8 ± 2

0.045 ± 0.019

0.59

0.576

0.66

0.547

0.414

0.369

0.735

0.48

0.884

0.434

0.512

0.805

DSE

Abnormal

5.8 ± 2

4.9 ± 1.4

2.5 ± 0. 7

6 ± 2

6.3 ± 1.5

5.1 ± 2.5

6.5 ± 2.2

6.6 ± 1.6

6 ± 2

6.5 ± 2

6 ± 2.2

0.039 ± 0.006

Normal

7 ± 3

5.6 ± 1.9

3 ± 1.3

6.3 ± 2.4

6.6 ± 2.6

5.49 ± 2.5

6.4 ± 1.5

6 ± 1.5

5.4 ± 1.5

5.4 ± 1.6

5.9 ± 1.3

0.04 ± 0.017

0.0795

0.207

0.122

0.47

0.63

0.375

0.93

0.326

0.29

0.122

0.77

0.46

Abnormal

0.147

0.25

2.93 × 10^-5

0.823

0.903

0.619

0.947

0.549

0.57

0.749

0.513

0.33

(rest:DSE)

Normal

0.83

0.32

5.15 × 10^-11

0.96

0.57

0.482

0.865

0.269

0.85

0.575

0.663

0.41

**Table 4.** Right Ventricular Global and Regional Diastolic Peak Velocities and Ratios at Rest and After Stress
		TV-E (cm/s)	TV-A (cm/s)	TV-E/A	E_RV (cm/s)	A_RV (cm/s)	TV-E/E_RV	TV-E/E_IVS	TV-A/A_RV	TV-A/A_IVS
TV: tricuspid valve; other abbreviations like in previous tables.
Rest	Abnormal	49.8 ± 17	44.9 ± 10	1.15 ± 0.38	16.79 ± 7.15	19.4 ± 5.3	4 ± 2.8	5.8 ± 1.4	4 ± 1.2	3.85 ± 1.08
Normal	57 ± 13	57.7 ± 14	1.04 ± 0.296	16.3 ± 3.9	20.1 ± 6.1	3.6 ± 0.01	5.3 ± 2.2	4.5 ± 1.9	4.53 ± 1.46
P	0.27	0.01	0.466	0.8403	0.74	0.72	0.432	0.805	0.186
DSE	Abnormal	70 ± 15	77.9 ± 226	0.94 ± 0.21	17.4 ± 8.6	26.7 ± 4.1	5.6 ± 2.8	6.33 ± 1.27	3.9 ± 0.6	4.59 ± 0.93
Normal	65 ± 12	82.4 ± 21	0.84 ± 0.24	17 ± 5.9	28.3 ± 6.8	4.4 ± 1.8	5.6 ± 2.4	4 ± 1.7	4.45 ± 1.29
P	0.45	0.623	0.26	0.884	0.36	0.24	0.25	0.46	0.774
P (rest:DSE)	Abnormal	0.022	0.004	0.198	0.853	0.005	0.23	0.427	0.33	0.173
Normal	0.0168	1.15 × 10^-5	0.0069	0.503	2.4 × 10^-7	0.046	0.6212	0.41	0.859

Table 4. Right Ventricular Global and Regional Diastolic Peak Velocities and Ratios at Rest and After Stress

TV-E (cm/s)

TV-A (cm/s)

TV-E/A

E_RV (cm/s)

A_RV (cm/s)

TV-E/E_RV

TV-E/E_IVS

TV-A/A_RV

TV-A/A_IVS

TV: tricuspid valve; other abbreviations like in previous tables.

Rest

Abnormal

49.8 ± 17

44.9 ± 10

1.15 ± 0.38

16.79 ± 7.15

19.4 ± 5.3

4 ± 2.8

5.8 ± 1.4

4 ± 1.2

3.85 ± 1.08

Normal

57 ± 13

57.7 ± 14

1.04 ± 0.296

16.3 ± 3.9

20.1 ± 6.1

3.6 ± 0.01

5.3 ± 2.2

4.5 ± 1.9

4.53 ± 1.46

0.27

0.01

0.466

0.8403

0.74

0.72

0.432

0.805

0.186

DSE

Abnormal

70 ± 15

77.9 ± 226

0.94 ± 0.21

17.4 ± 8.6

26.7 ± 4.1

5.6 ± 2.8

6.33 ± 1.27

3.9 ± 0.6

4.59 ± 0.93

Normal

65 ± 12

82.4 ± 21

0.84 ± 0.24

17 ± 5.9

28.3 ± 6.8

4.4 ± 1.8

5.6 ± 2.4

4 ± 1.7

4.45 ± 1.29

0.45

0.623

0.26

0.884

0.36

0.24

0.25

0.46

0.774

P (rest:DSE)

Abnormal

0.022

0.004

0.198

0.853

0.005

0.23

0.427

0.33

0.173

Normal

0.0168

1.15 × 10^-5

0.0069

0.503

2.4 × 10^-7

0.046

0.6212

0.41

0.859