Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 7, Number 2, April 2016, pages 59-65

Interesting Correlation Between the Circulating Pentraxin 3 and Cardiac Rehabilitation Program Outcomes in Coronary Artery Bypass Grafting Patients

Figure 1. Distribution of MET among the patients undergoing CABG assigned to each PTX3 group. (a) Before cardiac rehabilitation. (b) After cardiac rehabilitation. MET: metabolic equivalent test; CABG: coronary artery bypass grafting; PTX3: pentraxin 3.

Figure 2. Distribution of EF% among the patients undergoing CABG assigned to each PTX3 group. (a) Before cardiac rehabilitation. (b) After cardiac rehabilitation. EF: ejection fraction; CABG: coronary artery bypass grafting.

**Table 1.** Duke Activity Status Index (DASI)
DASI = SUM (values for all 12 questions)
Maximum value: 58.2, minimum value: 0
Estimated peak oxygen uptake in mL/min = 0.43 × (DASI)/9.6
1 MET is equivalent to a metabolic rate consuming 3.5 mL of oxygen per kg of body weight per min
DASI = sum of yes replies
VO_2peak = (0.43 × DASI) + 9.6
VO_2peak = mL/kg/min/(3.5 mL/kg/min) = METs

Table 1. Duke Activity Status Index (DASI)

DASI = SUM (values for all 12 questions)

Maximum value: 58.2, minimum value: 0

Estimated peak oxygen uptake in mL/min = 0.43 × (DASI)/9.6

1 MET is equivalent to a metabolic rate consuming 3.5 mL of oxygen per kg of body weight per min

DASI = sum of yes replies

VO_2peak = (0.43 × DASI) + 9.6

VO_2peak = mL/kg/min/(3.5 mL/kg/min) = METs

**Table 2.** Demographic Data of the Patients Participated in This Study
Data are presented as number (%) or mean. SYNTAX: synergy between percutaneous coronary intervention with Taxus and cardiac surgery; CRP: C-reactive protein.
Male/female (%)	46/54
Age (years)	61.76 ± 8.22
SYNTAX score	33.18 ± 1.64
Smokers (%)	20%
Hyperlipidemia (%)	37%
Diabetes mellitus (%)	48%
Hypertension (%)	32%
High-density lipoprotein cholesterol (mmol/L)	1.01 ± 0.21
Total cholesterol (mmol/L)	5.89 ± 5.14

Table 2. Demographic Data of the Patients Participated in This Study

Data are presented as number (%) or mean. SYNTAX: synergy between percutaneous coronary intervention with Taxus and cardiac surgery; CRP: C-reactive protein.

Male/female (%)

46/54

Age (years)

61.76 ± 8.22

SYNTAX score

33.18 ± 1.64

Smokers (%)

20%

Hyperlipidemia (%)

37%

Diabetes mellitus (%)

48%

Hypertension (%)

32%

High-density lipoprotein cholesterol (mmol/L)

1.01 ± 0.21

Total cholesterol (mmol/L)

5.89 ± 5.14

**Table 3.** Echocardiographic and Circulating Indicators Value of the Patients Before and After the Cardiac Rehabilitation Program
	Before CR	After CR	P value
Data are presented as mean ± SD. CR: cardiac rehabilitation; EF: ejection fraction; MET: peak exercise capacity measured in metabolic equivalents; PTX3: pentraxin 3; CRP: C-reaction protein.
EF (%)	31.89 ± 7.65	33.88 ± 8.73	< 0.05
MET	4.47 ± 1.32	5.16 ± 1.96	< 0.05
PTX3 (ng/dL)	0.469 ± 0.096	0.380 ± 0.051	< 0.05
hs-CRP (mg/dL)	3.85 ± 2.78	3.72 ± 2.61	0.546

Table 3. Echocardiographic and Circulating Indicators Value of the Patients Before and After the Cardiac Rehabilitation Program

Before CR

After CR

P value

Data are presented as mean ± SD. CR: cardiac rehabilitation; EF: ejection fraction; MET: peak exercise capacity measured in metabolic equivalents; PTX3: pentraxin 3; CRP: C-reaction protein.

EF (%)

31.89 ± 7.65

33.88 ± 8.73

< 0.05

MET

4.47 ± 1.32

5.16 ± 1.96

< 0.05

PTX3 (ng/dL)

0.469 ± 0.096

0.380 ± 0.051

< 0.05

hs-CRP (mg/dL)

3.85 ± 2.78

3.72 ± 2.61

0.546

**Table 4.** The Number of the Patients in Each EF Group Pre- and Post-CR Program Based on Pre-PTX3 Values
	EF (%)
EF: ejection fraction; pre-pentraxin 3: pentraxin 3 values before cardiac rehabilitation program; pre: before cardiac rehabilitation; post: after cardiac rehabilitation.
Pre-pentraxin 3 (ng/dL)
< 0.40	9	8	15	14	3	4	2	2	1	2
0.40 - 0.55	14	10	9	8	7	9	8	5	9	15
> 0.55	4	1	6	6	3	3	3	4	7	9

Table 4. The Number of the Patients in Each EF Group Pre- and Post-CR Program Based on Pre-PTX3 Values

EF (%)

< 25

25 - 30

30 - 35

35 - 40

> 40

Pre

Post

Pre

Post

Pre

Post

Pre

Post

Pre

Post

EF: ejection fraction; pre-pentraxin 3: pentraxin 3 values before cardiac rehabilitation program; pre: before cardiac rehabilitation; post: after cardiac rehabilitation.

Pre-pentraxin 3 (ng/dL)

< 0.40

0.40 - 0.55

> 0.55

**Table 5.** The Number of the Patients in Each MET Group Pre- and Post-CR Program Based on Pre-PTX3 Values
	MET
MET: peak exercise capacity measured in metabolic equivalents; pre-pentraxin 3: pentraxin 3 values before cardiac rehabilitation program; pre: before cardiac rehabilitation; post: after cardiac rehabilitation.
Pre-pentraxin 3 (ng/dL)
< 0.40	13	12	13	15	4	3	0	0
0.40 - 0.55	10	9	26	17	11	13	0	8
> 0.55	3	0	12	8	6	7	2	8

Table 5. The Number of the Patients in Each MET Group Pre- and Post-CR Program Based on Pre-PTX3 Values

MET

< 3

3 - 5

5 - 8

8 - 10

Pre

Post

Pre

Post

Pre

Post

Pre

Post

MET: peak exercise capacity measured in metabolic equivalents; pre-pentraxin 3: pentraxin 3 values before cardiac rehabilitation program; pre: before cardiac rehabilitation; post: after cardiac rehabilitation.

Pre-pentraxin 3 (ng/dL)

< 0.40

0.40 - 0.55

> 0.55