Cardiol Res

Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access

Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc

Journal website https://www.cardiologyres.org

Original Article

Volume 7, Number 3, June 2016, pages 89-94

Early Changes in the Antithrombin and Thrombin-Antithrombin Complex in Patients With Paroxysmal Atrial Fibrillation

Figure 1. Comparison of AT plasma levels in patients with PAF and controls in sinus rhythm (*P < 0.001).

Figure 2. Comparison of AT activity in plasma in patients with PAF and controls in sinus rhythm (*P < 0.001).

Figure 3. Comparison of TAT complex levels in plasma in patients with PAF and controls in sinus rhythm (*P < 0.001).

**Table 1.** Patient and Control Group Clinical Data
	Patients with PAF	Control group	P values
Less than 0.5 pack (10 cigarettes)/week. Hospitalized patients had not smoked at least 24 h prior to the arrhythmia. Data from controls were taken after a 48-h non-smoking period. *No more than 2 drinks/week. Hospitalized patients had at least a 48-h period without alcohol prior to the arrhythmia. Data from controls were taken after a 48-h period without alcohol.
Number of participants in the group	51	52	0.89
Mean age (years)	59.84 ± 1.60	59.50 ± 1.46	0.87
Men/women	26/25	26/26	1/0.93
Accompanying diseases
Hypertension	37 (72.54%)	34 (65.38%)	0.44
Diabetes mellitus type 2	3 (5.88%)	2 (3.84%)	0.62
Chronic ulcer disease	2 (3.92%)	0	0.15
Status after hysterectomy	2 (3.92%)	1 (1.92%)	0.54
Benign prostatic hyperthrophy	1 (1.96%)	0	0.32
Dyslipidemia	4 (7.84%)	3 (5.77%)	0.69
Medicaments for hypertension and dyslipidemia
Beta blockers	19 (37.25%)	17 (32.69%)	0.62
ACE inhibitors	15 (29.41%)	14 (26.92%)	0.78
Sartans	11 (21.57%)	9 (17.31%)	0.58
Statins	4 (7.84%)	3 (5.77%)	0.69
Deleterious habits
Smoking*	8 (15.69%)	7 (13.46%)	0.75
Alcohol intake**	7 (13.72%)	6 (11.53%)	0.74
BMI (kg/m²)	23.85 ± 0.46	24.95 ± 0.45	0.09

Table 1. Patient and Control Group Clinical Data

Patients with PAF

Control group

P values

*Less than 0.5 pack (10 cigarettes)/week. Hospitalized patients had not smoked at least 24 h prior to the arrhythmia. Data from controls were taken after a 48-h non-smoking period. **No more than 2 drinks/week. Hospitalized patients had at least a 48-h period without alcohol prior to the arrhythmia. Data from controls were taken after a 48-h period without alcohol.

Number of participants in the group

0.89

Mean age (years)

59.84 ± 1.60

59.50 ± 1.46

0.87

Men/women

26/25

26/26

1/0.93

Accompanying diseases

Hypertension

37 (72.54%)

34 (65.38%)

0.44

Diabetes mellitus type 2

3 (5.88%)

2 (3.84%)

0.62

Chronic ulcer disease

2 (3.92%)

0.15

Status after hysterectomy

2 (3.92%)

1 (1.92%)

0.54

Benign prostatic hyperthrophy

1 (1.96%)

0.32

Dyslipidemia

4 (7.84%)

3 (5.77%)

0.69

Medicaments for hypertension and dyslipidemia

Beta blockers

19 (37.25%)

17 (32.69%)

0.62

ACE inhibitors

15 (29.41%)

14 (26.92%)

0.78

Sartans

11 (21.57%)

9 (17.31%)

0.58

Statins

4 (7.84%)

3 (5.77%)

0.69

Deleterious habits

Smoking*

8 (15.69%)

7 (13.46%)

0.75

Alcohol intake**

7 (13.72%)

6 (11.53%)

0.74

BMI (kg/m²)

23.85 ± 0.46

24.95 ± 0.45

0.09

**Table 2.** Echocardiographic Indices of Patient and Control Group
Echocardiographic indicators	Patients with PAF	Control group	P values
LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; EF: ejection fraction; IVS: interventricular septum; PW: posterior wall; LA: left atrium; RVEDD: right ventricular end-diastolic volume.
LVEDD (mm)	52.57 ± 0.58	52.29 ± 0.57	0.73
LVESD (mm)	34.43 ± 0.56	34.73 ± 0.48	0.69
EF (%)	62.98 ± 0.70	61.54 ± 0.58	0.12
IVS (mm)	10.37 ± 0.23	9.92 ± 0.26	0.20
PW (mm)	10.24 ± 0.21	9.73 ± 0.28	0.16
LA volume (mL/m²)	22.81 ± 0.45	23.82 ± 0.48	0.13
RVEDD (mm)	30.54 ± 1.58	29.17 ± 1.52	0.18

Table 2. Echocardiographic Indices of Patient and Control Group

Echocardiographic indicators

Patients with PAF

Control group

P values

LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; EF: ejection fraction; IVS: interventricular septum; PW: posterior wall; LA: left atrium; RVEDD: right ventricular end-diastolic volume.

LVEDD (mm)

52.57 ± 0.58

52.29 ± 0.57

0.73

LVESD (mm)

34.43 ± 0.56

34.73 ± 0.48

0.69

EF (%)

62.98 ± 0.70

61.54 ± 0.58

0.12

IVS (mm)

10.37 ± 0.23

9.92 ± 0.26

0.20

PW (mm)

10.24 ± 0.21

9.73 ± 0.28

0.16

LA volume (mL/m²)

22.81 ± 0.45

23.82 ± 0.48

0.13

RVEDD (mm)

30.54 ± 1.58

29.17 ± 1.52

0.18