Figure 1. Distribution of average luminal diameter narrowing across four major coronary arteries (n = 513).
| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
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Original Article
Volume 8, Number 1, February 2017, pages 1-6
Sex Differences of the Natriuretic Peptide Polymorphism Associated With Angiographic Coronary Atherosclerosis
Figure
Tables
| Characteristics | Mean ± SD or percent |
|---|---|
| Age (years) | 65.3 ± 11.1 |
| Sex male | 63.94% |
| Caucasian | 98.2% |
| BMI (kg/m2) | 30.3 ± 6.3 |
| Current smoker | 18.8% |
| Hypertension | 65.1% |
| Diabetes | 31.3% |
| Previous MI | 28.0% |
| Family history of heart diseases | 67.7% |
| CAD categories | |
| Normal coronary | 22.6% |
| Non-obstructive CAD | 21.3% |
| Obstructive CAD | 56.1% |
| SNP ID (major allele/minor allele) | n | Genotypes | |||
|---|---|---|---|---|---|
| Homozygous major allele (n, %) | Heterozygous (n, %) | Homozygous minor allele (n, %) | MAF | ||
| MAF: minor allele frequency. | |||||
| NPPA rs5065 (A/G) | 510 | 375 (73.5%) | 119 (23.3%) | 16 (3.1%) | 0.15 |
| NPPB rs198389 (A/G) | 490 | 174 (34.2%) | 257 (50.5%) | 78 (15.3%) | 0.42 |
| NPR2 rs10758325 (G/A) | 507 | 176 (34.7%) | 249 (49.0%) | 83 (16.3%) | 0.41 |
| SNP | Genotype | Obstructive CAD | |||
|---|---|---|---|---|---|
| Overall RR (95% CI) | Male RR (95% CI) | Female RR (95% CI) | P-value (sex difference) | ||
| *P < 0.05. Adjusted for age and sex. | |||||
| NPPA rs5065 (n = 510) | AA | 1.04 (0.88 - 1.22) | 0.99 (0.83 - 1.16) | 1.31 (0.88 - 1.95) | 0.199 |
| AG/GG | Reference | Reference | Reference | ||
| NPPB rs198389 (n = 509) | AA | 1.00 (0.87 - 1.16) | 0.93 (0.79 - 1.10) | 1.50 (1.09 - 2.07)* | 0.015 |
| AG/GG | Reference | Reference | Reference | ||
| NPR2 rs10758325 (n = 508) | GG | 1.02 (0.88 - 1.18) | 1.04 (0.90 - 1.22) | 0.90 (0.63 - 1.28) | 0.443 |
| GA/AA | Reference | Reference | Reference | ||
| SNP | Genotype | Average luminal narrowing | |||
|---|---|---|---|---|---|
| Overall β (95% CI) | Male β (95% CI) | Female β (95% CI) | P-value (sex difference) | ||
| *P < 0.05. †P < 0.01. Adjusted for age and sex. | |||||
| NPPA rs5065 (n = 385) | AA | 1.39 (-3.43 - 6.21) | -1.37 (-7.25 - 4.51) | 6.95 (-1.39 - 15.30) | 0.110 |
| AG/GG | Reference | Reference | Reference | ||
| NPPB rs198389 (n = 385) | AA | 4.91 (0.50 - 9.32)* | 1.92 (-3.44 - 7.28) | 11.05 (3.37 - 18.73)† | 0.057 |
| AG/GG | Reference | Reference | Reference | ||
| NPR2 rs10758325 (n = 383) | GG | 0.65 (-3.84 - 5.14) | -0.37 (-5.79 - 5.05) | 2.88 (-5.14 - 10.91) | 0.511 |
| GA/AA | Reference | Reference | Reference | ||