Figure 1. Comparison between antiplatelet drugs for clinical outcome of the composite adverse event.
| Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc |
| Journal website https://www.cardiologyres.org |
Original Article
Volume 8, Number 3, June 2017, pages 105-110
Comparison of Clopidogrel With Prasugrel and Ticagrelor in Patients With Acute Coronary Syndrome: Clinical Outcomes From the National Cardiovascular Database ACTION Registry
Figures
Tables
| Characteristics | n = 1,388 | P-value |
|---|---|---|
| *Statistical significance. | ||
| Age, years (mean ± SD) | 63 ± 14 | < 0.001* |
| Female gender (%) | 34 | 0.067 |
| Caucasian (%) | 83 | 0.43 |
| Body mass index (kg/m2) (mean ± SD) | 30 ± 8 | 0.055 |
| STEMI EKG (%) | 46 | 0.003* |
| History of heart failure (%) | 13 | < 0.001* |
| Diabetes (%) | 31 | 0.032* |
| Dyslipidemia (%) | 61 | 0.047* |
| Hypertension (%) | 72 | < 0.001* |
| Peripheral arterial disease (%) | 10 | 0.22 |
| Prior coronary artery bypass surgery (%) | 18 | 0.32 |
| Prior myocardial infarction (%) | 29 | 0.083 |
| Prior PCI (%) | 27 | 0.64 |
| History of stroke (%) | 9 | 0.008* |
| History of transient ischemic attack (%) | 2 | 0.01* |
| History of cerebrovascular disease (%) | 14 | 0.01* |
| Dialysis-dependent end-stage renal disease (%) | 1.5 | 0.52 |
| Current tobacco use (%) | 39 | 0.061 |
| Outcome | Clopidogrel (n = 1,012) | Prasugrel (n = 244) | Ticagrelor (n = 142) | OR (95% CI) (clopidogrel to prasugrel) | OR (95% CI) (clopidogrel to ticagrelor) |
|---|---|---|---|---|---|
| *Odds ratio (OR) with statistical significance (P < 0.05). “-” denotes where ORs are undefined and therefore could not be computed. AF: atrial fibrillation; VT/VF: ventricular tachycardia/ventricular fibrillation; MV: mechanical ventilation; CS: cardiogenic shock; HF: heart failure; OR: odds ratio; CI: confidence interval. | |||||
| AF (%) | 5 | 0 | 6 | - | 0.73 (0.22 - 2.45) |
| VT/VF (%) | 4 | 9 | 9 | 0.44 (0.09 - 2.23) | 0.42 (0.14 - 1.25) |
| MV (%) | 2 | 0 | 3 | - | 0.49 (0.08 - 2.98) |
| CS (%) | 4 | 6 | 5 | 0.76 (0.41 - 1.42) | 0.83 (0.37 - 1.88) |
| HF (%) | 10 | 4 | 5 | 2.96 (1.47 - 5.94)* | 2.02 (0.92 - 4.45) |
| Bleeding (%) | 4 | 1 | 3 | 5.5 (1.32 - 22.85)* | 1.45 (0.51 - 4.12) |
| Composite event (%) | 15 | 9 | 16 | 1.76 (1.1 - 2.81)* | 0.92 (0.56 - 1.51) |