Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website https://www.cardiologyres.org

Original Article

Volume 9, Number 3, June 2018, pages 144-152

Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

Figures

Figure 1.
Figure 1. Flow diagram for study identification and inclusion.
Figure 2.
Figure 2. Forest plot showing pooled risk ratio of RDW and all-cause or cardiovascular mortality.
Figure 3.
Figure 3. Subgroup analysis according to duration of follow-up (< 1 year vs. ≥ 1 year).
Figure 4.
Figure 4. Subgroup analysis according to study design (prospective vs. retrospective).
Figure 5.
Figure 5. Funnel plot for RDW and all-cause or cardiovascular mortality.
Figure 6.
Figure 6. Forest plot showing pooled risk ratio of RDW and major adverse cardiovascular events (MACEs).

Tables

Table 1. Characteristics of Studies Included in Meta-Analysis
 
Author and year of publicationStudy designPopulationPopulation sizeMortality outcomeMACEs evaluatedDuration of follow-up
MACE: major adverse cardiovascular event; CAD: coronary artery disease; ACS: acute coronary syndrome; NSTE-ACS: non-ST elevation acute coronary syndrome; AMI: acute myocardial infarction; STEMI: ST elevation myocardial infarction; PCI: percutaneous coronary intervention; CA: coronary angiography; CV: cardiovascular; HF: heart failure; NYHA: New York Heart Association.
Azab et al (2011) [17]RetrospectiveNSTEMI619All-cause mortality-4 years
Bekler et al (2015) [18]RetrospectiveNSTE-ACS202CV mortalityReinfarction18 months (median)
Repeat revascularization
Cavusoglu et al (2010) [19]ProspectiveACS subgroup of male patients referred for CA189All-cause mortality-2 years
Dabbah et al (2010) [20]ProspectiveAMI1,709All-cause mortality-27 months (median)
Ghaffari et al (2016) [21]ProspectivePost-thrombolysis STEMI312All-cause mortalityCardiogenic shock7.7 months (mean)
Acute HF
Delayed ventricular dysrhythmias
Gul et al (2012) [22]ProspectiveNSTE-ACS310CV mortalityReinfarction3 years
Stroke
Rehospitalization for HF
Ilhan et al (2012) [23]RetrospectiveAMI undergoing primary PCI763CV mortality-In-hospital
Isik et al (2012) [24]ProspectiveSTEMI undergoing primary PCI100CV mortalityReinfarction6 months
Repeat revascularization
Sun et al (2014) [25]RetrospectiveSTEMI free of HF at baseline667All-cause mortality-41.8 months (mean)
Turcato et al (2016) [26]RetrospectiveACS979All-cause mortalityReinfarction3 months
Repeat revascularization
Uyarel et al (2011) [27]RetrospectiveSTEMI undergoing primary PCI2,506CV mortalityReinfarction21 months (median)
Repeat revascularization Advanced HF (NYHA III)
Wang et al (2011) [28]ProspectiveACS1,654CV mortalityReinfarction1 month
Rehospitalization for HF
Zorlu et al (2015) [29]RetrospectiveACS undergoing CA400All-cause mortalityReinfarction15 months (mean)

 

Table 2. Quality Assessment of Included Studies Using Newcastle-Ottawa Scale
 
Author and year of publicationSelectionComparabilityOutcomeTotal rating
Azab et al (2011) [17]★★★★★★★★★9★
Bekler et al (2015) [18]★★★★★★★★★9★
Cavusoglu et al (2010) [19]★★★★★★★7★
Dabbah et al (2010) [20]★★★★★★★★★9★
Ghaffari et al (2016) [21]★★★★★★★★★9★
Gul et al (2012) [22]★★★★★★★★★9★
Ilhan et al (2012) [23]★★★★★★★7★
Isik et al (2012) [24]★★★★★★★★8★
Sun et al (2014) [25]★★★★★★★★8★
Turcato et al (2016) [26]★★★★★★★★8★
Uyarel et al (2011) [27]★★★★★★★★8★
Wang et al (2011) [28]★★★★★★★★8★
Zorlu et al (2015) [29]★★★★★★★★★9★