Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website http://www.cardiologyres.org

Original Article

Volume 9, Number 6, December 2018, pages 343-349

Influence of Beta-1 Adrenergic Receptor Genotype on Cardiovascular Response to Exercise in Healthy Subjects

Figures

Figure 1.
Figure 1. Panels depict the change from rest to peak exercise in (a) cardiac output (Q), (b) systolic blood pressure (BPsys), (c) diastolic blood pressure (BPdias), and (d) stroke volume (SV). The error bars represent the SE of the mean. †Possible trend towards significance for change in BPsys (P = 0.08) and SV (P = 0.058) from rest to peak between genotype groups. ∫Clinically significant difference between genotype groups for change in BPdias from rest to peak exercise (-5.5 ± 15.4 and 1.3 ± 11.5 for Ser49Ser and Gly49Ser, respectively).
Figure 2.
Figure 2. Panels depict the change from rest to peak exercise in (a) cardiac index (CI), (b) heart rate (HR) and (c) systemic vascular resistance (SVR). The error bars represent the SE of the means. *P < 0.05 for Ser49Ser vs. Gly49Ser pairwise comparisons.

Table

Table 1. Subject Characteristics
 
Study demographicsNo.Mean ± SDP-value
Ser49Ser: genotype (homozygous for ADRB1 resulting in serine at amino acid 49); Gly49Ser: genotype (heterozygous for ADRB1 resulting in one glycine and one serine at amino acid 49); BMI: body mass index. There were no statistically significant differences in demographic data.
Sex (Male/female)
  Ser49Ser26/26--
  Gly49Ser10/9--
  Total36/35--
Age (yrs)
  Ser49Ser5228.9 ± 5.60.25
  Gly49Ser1930.6 ± 6.4
  Total7129.3 ± 5.8
Height (cm)
  Ser49Ser52173.6 ± 9.90.87
  Gly49Ser19174 ± 7.4
  Total71173.7 ± 9.3
Weight (kg)
  Ser49Ser5274.4 ± 13.30.5
  Gly49Ser1971.9 ± 13.5
  Total7173.8 ± 13.3
BMI
  Ser49Ser5224.6 ± 3.50.33
  Gly49Ser1923.6 ± 3.3
  Total7124.3 ± 3.4
Watts
  Ser49Ser52223.8 ± 76.80.33
  Gly49Ser19205 ± 49.4
  Total71218.7 ± 70.6