Cardiology Research, ISSN 1923-2829 print, 1923-2837 online, Open Access
Article copyright, the authors; Journal compilation copyright, Cardiol Res and Elmer Press Inc
Journal website http://www.cardiologyres.org

Review

Volume 10, Number 2, April 2019, pages 69-73

Atherosclerotic Coronary Artery Disease in Patients With Cardiometabolic Syndrome

Figure

Figure 1.
Figure 1. (a) Relationship between combination of HDL-C < 40 mg/dL and LDL-C ≥ 100 mg/dL and major adverse cardiac events after percutaneous coronary intervention. (b) Serum levels of HDL-C in patients with and without CAD in statin (-) and statin (+) groups. *P < 0.05 versus CAD (-). (c) Association between the numbers of significant VD in coronary artery disease. (d) Association between serum levels of TG and % lipid volume in women. HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; CAD: coronary artery disease; OR: odds ratio; VD: stenosed vessels; TG: triglyceride.

Tables

Table 1. Residual Risks of Cardiovascular Disease
 
LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglyceride.
Insufficient reduction of serum LDL-C levels
Low levels of serum HDL-C and elevated serum TG levels
Insufficient control of other risk factors (high blood pressure, obesity, metabolic syndrome, type 2 diabetes, etc.)

 

Table 2. Summary of Three FU Registries in Japan
 
Registry nameChief researcher
FU: Fukuoka University; QCA: Quantitative Coronary Angiography; LDL-C: low-density lipoprotein cholesterol; MACEs: major adverse cardiac events; CCTA: Coronary Computed Tomography Angiography; HDL-C: high-density lipoprotein cholesterol; CAD: coronary artery disease; IVUS: Coronary Intravascular Ultrasound; TG: triglyceride.
FU-QCA Registry: In female patients, HDL-C < 40 mg/dL and LDL-C ≥ 100 mg/dL were more strongly related to MACEs after adjusting for various factors including statin treatment. On the other hand, the combination was not related to MACEs in male patients.Dr. Ike
FU-CCTA Registry: The number of significantly stenosed coronary vessels significantly increased as the number of metabolic factors increased. Lower levels of HDL-C may be most useful for predicting CAD independent of statin treatment.Dr. Shiga
FU-IVUS Registry: TG levels may be more important indicators of residual risk after statin treatment in women than in men.Dr. Iwata