ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population

A. Syed Sameer, Nidda Syeed, Shahid A. Tak, Samina Bashir, Saniya Nissar, Mushtaq A. Siddiqi

Abstract


Background: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population.

Materials and Methods: We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fishers Chi square test was used for calculation of P value and OR.

Results: We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases.

Conclusions: The ACE I/D genotype is positively associated with hypertension in our population.




doi:10.4021/cr101e


Keywords


Hypertension; ACE; Polymorphism; RFLP; Kashmir

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