A Case Demonstrating the Ribaroxaban Therapy for Paradoxical Embolism

Hiroto Aikawa, Kazuhiro Shimizu, Mahito Noro


A paradoxical embolism is defined as a systemic arterial embolus due to passage of a venous thrombus through a right to left shunt. In recent years, vitamin K antagonists and aspirin are used as anticoagulant medications for the secondary prevention of paradoxical embolism. We describe a case of subacute right upper limb ischemia due to paradoxical embolism. We first started treatment with urokinase, intravenous (IV) injection and unfractionated heparin (continuous IV). As her condition and the serum D-dimer level showed improvement, we started catheterization on day 7 after admission; however the right brachial artery thrombus did not disappear. For her outpatient care, based on the viewpoint of providing rapid anticoagulation therapy within the therapeutic range, having longest periods of initial intensive therapy we chose the treatment using ribaroxaban. Recanalization of her right brachial artery was achieved with this therapy. Here, we report the effective results of initial intensive therapy using ribaroxaban for paradoxical embolism.

Cardiol Res. 2019;10(1):63-67
doi: https://doi.org/10.14740/cr840


Paradoxical embolism; Ribaroxaban; PFO; VTE; DOACs

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