ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function

Fulvia Gloria-Bottini, Maria Banci, Patrizia Saccucci, Paolo Nardi, Mattia Scognamiglio, Federica Papetti, Sara Adanti, Andrea Magrini, Antonio Pellegrino, Egidio Bottini, Luigi Chiariello

Abstract


Background: Kinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), and Coronary artery disease (CAD) suggesting an effect on the susceptibility to this disease. In the present note we have investigated a possible role of ACP1 in the variability of clinical parameters of cardiac function. 

Methods: We have studied 345 subjects admitted to Valmontone Hospital for cardiovascular diseases: 202 subjects with CAD and 143 without CAD, 53 subjects admitted to Cardiac Surgery Division of Tor Vergata University were also considered. 

Results: In diabetic patients with CAD there is a significant negative association between Left ventricular ejection fraction (LVEF) and ACP1S isoform concentration. Genotypes with high S isoform concentration show a lower value of LVEF as compared to genotypes with low S isoform concentration. We have also found a significant positive association between cNYHA class and ACP1 S isoform. After surgical intervention, in subjects with high S isoform concentration the decrease of LVEF is more marked as compared to subjects with low S isoform concentration. Overall these observations indicate that high S isoform activity has negative effects on cardiac function. The observation in patients undergoing cardiac surgery confirms the negative association between high S isoform activity and LVEF. 

Conclusions: The present study suggests that ACP1 influences both susceptibility to CAD and clinical manifestations of the disease.




doi: http://dx.doi.org/10.4021/cr277w


Keywords


ACP1; CAD; LVEF; Genetic polymorphisms; Phosphatases; Cardiovascular diseases

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