Rivaroxaban Rebound Acute Coronary Event: A Post Marketing Experience

Abstract

We present a 65-year-old male who received rivaroxaban therapy prior to and after left knee replacement surgery. The patient developed generalized weakness soon after stopping rivaroxaban. An electrocardiogram showed acute infero-lateral ischemia and an echocardiogram reported an akinetic antero-apical wall segment, an apical clot and a reduced systolic function. A subsequent coronary angiogram revealed two-vessel coronary artery thrombosis. The case illustrates a temporal relationship of coronary thrombosis following rivaroxaban cessation.




Cardiol Res. 2013;4(6):207-210
doi: http://dx.doi.org/10.4021/cr294w